This track shows the topological domains defined by Hi-C analysis of Drosophila embryonic nuclei.
The Hi-C technique is based on Chromosome Conformation Capture (3C) and it provides an overview
of the three dimensional organization of the genome.
The Hi-C results were obtained from the
Comparative modENCODE / ENCODE
web site. The analysis results
were lifted from the D. melanogaster Release 5 assembly over to the Release 6 assembly.
The Hi-C analysis partitioned the genome into four discrete domains:
|Null||Null domains: weak enrichment of the insulator protein Su(Hw)|
|Active||Transcriptionally active: enriched in H3K4me3, H3K36me3, hyperacetylation|
|PcG||Polycomb: enriched in H3K27me3|
|HP1_Centromere||Classical heterochromatin: enriched in HP1, Su(var)3-9, H3K9me2|
Sexton T, Yaffe E, Kenigsberg E, Bantignies F, Leblanc B, Hoichman M, Parrinello H, Tanay A, Cavalli G.
Three-dimensional folding and functional organization principles of the Drosophila genome.
Cell. 2012 Feb 3;148(3):458-72.
Ho JW et al.
Comparative analysis of metazoan chromatin organization.
Nature. 2014 Aug 28;512(7515):449-52.